| | John Erwin | He-Man/Prince Adam, Ram-Man, Faker, Beast Man, Webstor, Whiplash, Granamyr, Oracle of the Crystal Sea, Tullamore (voice) |
| | Alan Oppenheimer | Battle Cat/Cringer, Man-At-Arms/Duncan, Skeletor, Mer-Man, Buzz-Off, Roboto, Melaktha (voice) |
| | Linda Gary | Teela, Evil-Lyn, Queen Marlena, The Sorceress/Teela-Na, Chad (voice) |
| | Lou Scheimer | Orko, King Randor, Stratos, Man-E-Faces, Mekaneck, Zodac, Sy-Klone, Moss Man, Trapjaw, Tri-Klops, Kobra Khan, Clawful, Jitsu, Spikor, Two-Bad, Galen Nycroft/Modulok (voice) |
| | Erika Scheimer | Additional female voices, alternate Queen Marlena (voice) |
